Relevance of ‘missing heritability’ in pharmacogenomics
نویسنده
چکیده
Pharmacogenomic biomarkers can optimize an individual’s therapy; however, the overall role of genetic factors in drug response remains uncertain. The majority of genetic variants currently used as clinical pharmacogenomic biomarkers affect drug metabolism and transport, while fewer biomarkers accurately predict drug response (pharmacodynamics). This article evaluates heritable aspects of drug therapy, highlighting gene-gene-environment interactions, in light of recent human evolution. These concepts are critical to the development of new drug therapies and biomarkers tests.
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